The mission of The University of Texas at Austin is to achieve excellence in the interrelated areas of undergraduate education, graduate education, research and public service. The University provides ...

Human telomerase is upregulated in most cancers, making it a prime therapeutic target, but a lack of structures in complex with inhibitors have hindered drug design. Here, cryo-electron microscopy ...

Targeted protein degradation eliminates disease-driving proteins by co-opting the ubiquitin–proteasome system. Now, a single degradation tail enables a molecular glue to hijack two E3 ubiquitin ...